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Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2142186.093    [Accepted] Published online May 16, 2022.
The association between idiopathic scoliosis and growth hormone treatment in short children
Mijin Park, Yu Jin Kim, Kyeong Eun Oh, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie  , Kee-Hyoung Lee
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
Address for correspondence:  Young-Jun Rhie
Email: human21@korea.ac.kr
Received: August 31, 2021   Revised: October 14, 2021   Accepted: October 25, 2021
Abstract
Purpose
Idiopathic scoliosis is the most common form of scoliosis, and the risk of both its onset and progression has been found to correlate with growth spurts. Therefore, recombinant human growth hormone (GH) treatment used in short children may affect both the initiation and aggravation of scoliosis. The aim of this study was to investigate the relationship between idiopathic scoliosis and GH treatment in short children.
Methods
The medical records of 113 subjects who were diagnosed with growth hormone deficiency, small for gestational age, and idiopathic short stature between January 2010 and December 2020 were reviewed. Scoliosis was defined as a Cobb angle of over 10° assessed using a spine X-ray. Clinical data and laboratory findings were compared between before and 12 months after GH treatment.
Results
There was a significant increase in height, height-standard deviation scores, insulin-like growth factor 1, and insulin-like growth factor binding protein 3 (P < 0.001) with GH treatment. However, there were no significant differences in the average Cobb angle (6.2±3.3° vs. 6.1±3.5°, P = 0.842) and the prevalence of scoliosis (9.7% vs. 13.3%, P = 0.481) between before and after one year of GH treatment. A comparative analysis of both the initial Cobb angle and the change in Cobb angle during GH treatment showed no relationship with other factors.
Conclusion
Although GH treatment in short children increases height and growth velocity, it is not associated with developing or aggravating idiopathic scoliosis.
Keywords: idiopathic scoliosis, growth hormone, short stature, growth hormone deficiency, small for gestational age, idiopathic short stature


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