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Ann Pediatr Endocrinol Metab > Volume 14(1); 2009 > Article
Clinical Course of Childhood and Adolescence Onset Type 2 Diabetes Mellitus.
Kyong Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea. chshinpd@snu.ac.kr
Abstract
PURPOSE
Worldwide incidence of type 2 diabetes mellitus in youth is increased for last 3 decades. We reviewed the clinical characteristics of the patients and their long term complications. METHODS:We reviewed the medical data of 69 patients who were diagnosed type 2 diabetes mellitus at Seoul National University Children's Hospital before the age of 18 years between January 1991 and December 2007.
RESULTS
Forty seven patients (68.1%) developed after 2000. The mean age of onset was 13.1+/-2.0 years. Forty seven (69.1%) patients had family history of diabetes mellitus and forty six (66.6%) patients had overweight or obesity. Thirteen (22.4%) patients were small for gestational age but their body mass index wasn't increased compared to that of appropriate for gestational age at the onset of disease. There were 7 patients who had microvascular complication and the mean disease duration was 9.1+/-3.3 years. Hemoglobin A1c was not increased in the complication group compared to the complication-free group.
CONCLUSION
The number of childhood and adolescence onset type 2 diabetes mellitus was increased. The proportion of small for gestation age was high and the long term complication developed in adolescence or early adult life. Early intervention of the risk factors and regular evaluation of the complications are needed and systematized follow-up of small for gestational age is also necessary.
Keywords: Diabetes Mellitus;Type 2;Infant;Small for gestational age;Diabetes complications;Adolescent;Childhood


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