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Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2346052.026    [Accepted] Published online November 9, 2023.
The influence of pituitary volume on the growth response in growth hormone-treated children with growth hormone deficiency and idiopathic short stature.
Jun Suk Oh1  , Beomseok Sohn2  , Youngha Choi3  , Kyungchul Song4  , Junghwan Suh5  , Ahreum Kwon5, Ho-Seong Kim5
1Department of Pediatrics, Konyang University Hospital, Daejeon, Korea
2Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea
3Department of Pediatrics, Kangwon National University Hospital, Kangwon, Korea
4Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
5Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea
Address for correspondence:  Ho-Seong Kim
Email: kimho@yuhs.ac
Received: February 24, 2023   Revised: May 1, 2023   Accepted: May 8, 2023
Abstract
Purpose
Magnetic resonance imaging (MRI) can be used for assessing the morphology of pituitary gland. The purpose of this study was 1) to determine whether the pituitary volume (PV) distinguish growth hormone (GH) deficiency from idiopathic short stature (ISS) and 2) to validate an association between PV and severity of GH deficiency and 3) to compare the PV between good and poor response groups in children with GH deficiency and ISS.
Methods
Data were collected from the medical records of 152 children with short stature who underwent GH stimulation test, sella MRI, and GH treatment. Estimated PV were calculated using the formula of an ellipsoid. We compared the PV in patients with GH deficiency with that of patients with ISS. In addition, we assessed the association between PV and severity of GH deficiency, and growth response after treatment.
Results
No difference was observed in the PV between patients with GH deficiency and ISS. The PV seemed to be smaller as the degree of GH deficiency was severe (P=0.082). The PV in good response group was smaller than that in poor response group in patients with GH deficiency (P< 0.005). The PV showed no association with responsiveness to GH treatment in patients with ISS (P=0.073).
Conclusions
The measurement of PV cannot be used for differential diagnosis between GH deficiency and ISS. In patients with GH deficiency, the PV tend to be smaller as the severity of GH deficiency even though no statistical significance, and may be a good response predictor for GH treatment.
Keywords: Dwarfism; Idiopathic short stature; Growth hormone deficiency; Growth response; Pituitary gland


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