J Korean Soc Pediatr Endocrinol Search

CLOSE


Ann Pediatr Endocrinol Metab > Volume 14(1); 2009 > Article
The Effect of Soy-based Formula on Infants' Bone Mineral Density.
Ji Yun Sim, Heon Seok Han
Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea. hshan@chungbuk.ac.kr
Abstract
PURPOSE
We compared the blood chemistry concerning calcium metabolism and bone mineral density (BMD) among the infants fed on soy-based formula (SF), breast milk feeding (BF) and casein-based formula (CF). METHODS:Fifty one term neonates delivered at Chungbuk National University Hospital from June 2001 to August 2003, were recruited. They were divided into three feeding groups (BF=20, SF=19, CF=12) by parent's own volition. Breast feeding and artificial formulae were given till three months of age, thereafter weaning food was added freely. Blood chemistry including calcium, phosphorus, and alkaline phosphatase were measured at 5, 12, and 36 months of age. BMD was measured at birth, 5, 12, and 36 months of age.
RESULTS
Serum calcium and alkaline phosphatase were not different among the three feeding groups until 36 months of age. At 5 months of age, serum phosphorus (P<0.05) and BMD (P<0.001) were significantly lower in SF group, but thereafter no difference was found in theses parameter until 36 months of age. After birth lumbar spine BMD decreased to the lowest level at 5 months and increased to the birth level at 36 months of age.
CONCLUSION
In spite of high mineral intake in SF group, the lowest serum phosphorus and lumbar BMD at 5 months of age suggest poor intestinal mineral absorption. Methods need to be developed to increase intestinal mineral absorption.
Keywords: Soy milk;Calcium;Phosphorus;Bone mineral density


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
501-107, 30 Seocho-daero 74-gil, Seocho-gu, Seoul 06622, Republic of Korea
Tel: +82-2-3471-4268    Fax: +82-2-3471-4269    E-mail: editor@e-apem.org                

Copyright © 2024 by Korean Society of Pediatric Endocrinology.

Developed in M2PI

Close layer
prev next