The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls.

Yoon,  Ju Young; Kang,  Min Jae; Kim,  Se Young; Seo,  Ji Young; Yang,  Sei Won; Lee,  Young Ah; Lee,  Ji Eun; Chung,  Hye Rim; Shin,  Choong Ho

doi:2011.16.3.165

Ann Pediatr Endocrinol Metab > Volume 16(3); 2011 > Article

Original Article

Journal of Korean Society of Pediatric Endocrinology 2011;16(3): 165-171.

DOI: https://doi.org/10.6065/jkspe.2011.16.3.165

The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls.

Ju Young Yoon, Min Jae Kang, Se Young Kim, Ji Young Seo, Sei Won Yang, Young Ah Lee, Ji Eun Lee, Hye Rim Chung, Choong Ho Shin

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. chshinpd@snu.ac.kr
²Department of Pediatrics, Bundang Jesaeng General Hospital, Seongnam, Korea.
³Department of Pediatrics, Eulji University School of Medicine, Seoul, Korea.
⁴Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

PURPOSE
The aim of this study is to evaluate the relationship between initial body mass index (BMI) and BMI after gonadotropin-releasing hormone agonist (GnRHa) treatment in idiopathic true precocious puberty girls. METHODS: The subjects were 99 idiopathic true precocious puberty girls treated with GnRHa for more than 1 year. The patients were categorized into two groups according to initial BMI; normal weight group (BMI < 85 percentile) and overweight/obesity group (BMI > or = 85 percentile). We investigated chronologic age (CA), bone age (BA), BA advancement (BA-CA), height (Ht), Ht-standard deviation score (Ht_zs), BMI, BMI_zs, predicted adult height (PAH), and PAH_zs before initiation of GnRHa treatment and 1 year later.
RESULTS
Baseline CA, BA, BA-CA, Ht_zs, and PAH showed no differences between normal weight group and overweight/obesity group. BMI_zs increased only in normal weight group, and DeltaBMI_zs was negatively correlated with initial BMI_zs (r = -0.501, P < 0.001). PAH_zs increased less in normal weight group (DeltaPAH_zs = 0.30) than in overweight/obesity group (DeltaPAH_zs = 0.66) (P = 0.02), but there was no correlation between initial BMI_zs and DeltaPAH_zs. DeltaBA-CA and DeltaHt_zs were not different between two groups either. Comparing patients with increased BMI_zs with those whose BMI_zs decreased or remained the same, there were no differences in DeltaBA-CA, DeltaHt_zs, and DeltaPAH_zs. On multiple regression analysis, DeltaBMI_zs was negatively correlated with initial BMI_zs, and it showed no correlation with CA, BA, BA-CA, height, and dose of GnRHa.
CONCLUSION
BMI_zs increased after 1yr of GnRHa treatment in idiopathic true precocious puberty girls whose initial BMI_zs was normal, and its increment was negatively correlated with initial BMI_zs.

Keywords: Puberty, precocious;Gonadotropin-releasing hormone agonist;Body mass index;Obesity