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Ann Pediatr Endocrinol Metab > Volume 14(2); 2009 > Article
Two Cases of Slipped Capital Femoral Epiphysis in Children Receiving Growth Hormone Therapy.
Hwan Seok Lee, Eun Ae Yang, Eun Hui Hong, Min Hyun Cho, Cheol Woo Ko
1Department of Pediatrics, CHA Gumi Medical Center, CHA University, Gumi, Korea.
2Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea. cwko@knu.ac.kr
Slipped capital femoral epiphysis is a rare hip disorder that mainly occurs in pubertal children. Although the exact cause of this disorder is unknown, it is known to be associated with obesity, trauma, delayed sexual development, delayed bone maturation, chronic renal failure, genetic diseases, endocrine disorders (growth hormone deficiency, hypothyroidism, hypogonadism), growth hormone therapy, and gonadotropin releasing hormone agonist (GnRH agonist) therapy. We report 2 cases of slipped capital femoral epiphysis in adolescent females who were receiving growth hormone therapy. The first case is of a 16 year-old-girl with chronic renal failure and renal osteodystrophy. The second case is of an 11 year-old-girl with idiopathic precocious puberty who had received GnRH agonist and growth hormone therapy. Unilateral or bilateral slipped capital femoral epiphysis developed at 1 year 3 months after treatment in both the cases. The chief complaints were pain in the hip joint and lower extremities. Growth hormone and/or GnRH agonist therapy was stopped, and in situ screw fixations of the involved hip epiphyses were performed.
Keywords: Slipped epiphysis;Growth hormone


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