A Case of Sjogren's Syndrome with Hyperthyroidism.

Jung,  Yun Hye; Choi,  Im Jeong; Jung,  Jin Wha

Ann Pediatr Endocrinol Metab > Volume 12(2); 2007 > Article

Case Report

Journal of Korean Society of Pediatric Endocrinology 2007;12(2): 150-154.

A Case of Sjogren's Syndrome with Hyperthyroidism.

Yun Hye Jung, Im Jeong Choi, Jin Wha Jung

Department of Pediatrics, Maryknoll Medical Center, Busan, Korea. whiteij@hanmail.net

Abstract

Sjogren syndrome is a chronic, slowly progressive, autoimmune disease in which the exocrine glands are damaged by lymphocytic infiltration, resulting in xerostomia and xerophthalmia. Sjogren syndrome may occur in 2 forms: primary Sjogren syndrome, when the clinical manifestations of the syndrome are seen alone, and secondary Sjogren syndrome, when associated with another autoimmune disease, such as rheumatoid arthritis, systemic lupus erythromatosus, or scleroderma. Approximately one third of patients present with extraglandular manifestations: arthritis, Raynaud phenomenon, lymphadenopathy, lung involvement, vasculitis and peripheral nervous system involvement. About 10-50% of patients with Sjogren syndrome had evidence of thyroid disease, mainly hypothyroidism. Several inflammatory thyroid diseases are also considered to be autoimmune in origin. In this respect, the histologic picture of primary Sjogren syndrome exocrine glands and autoimmune thyroid glands show great similarities. Here, we report a new case of Sjogren syndrome accompanying with hyperthyroidism which affected a 10-year-old girl.